The newly operational European Public Prosecutor’s Office (EPPO) serves as an independent prosecutor of crimes affecting the financial interests of the E.U., and the application of its rules can be complicated. This article covers the highlights of a recent International Bar Association program that examined the structure and operations of the EPPO and its relationship with the E.U. countries that chose not to participate, with insights from prosecutors from Italy and Poland, as well as defense counsel. See “Five Considerations in Cross-Border Anti-Corruption Matters” (Sep. 4, 2019).